Journal article
Brain tissue microstructural and free-water composition 13 years after very preterm birth
C Kelly, T Dhollander, IH Harding, W Khan, R Beare, JL Cheong, LW Doyle, M Seal, DK Thompson, TE Inder, PJ Anderson
Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2022
Open access
Abstract
There have been many studies demonstrating children born very preterm exhibit brain white matter microstructural alterations, which have been related to neurodevelopmental difficulties. These prior studies have often been based on diffusion MRI modelling and analysis techniques, which commonly focussed on white matter microstructural properties in children born very preterm. However, there have been relatively fewer studies investigating the free-water content of the white matter, and also the microstructure and free-water content of the cortical grey matter, in children born very preterm. These biophysical properties of the brain change rapidly during fetal and neonatal brain development, a..
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Grants
Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
We thank members of the VIBeS and Developmental Imaging teams at the Murdoch Children's Research Institute, the Royal Children's Hospital Medical Imaging stafffor their assistance and expertise in the collection of the MRI data included in this study, and the children and families who participated. This research was supported by the Australian National Health and Medical Research Council [NHMRC; Project Grants 237117, 491209 and 1066555; Centre of Clinical Research Excellence 546519; Centre of Research Excellence 1060733 and 1153176; Investigator Grant 1176077 to PA; Career Development Fellowship 1085754 to DT and 1141354 to JC], an Australian Government Research Training Program (RTP) Scholarship and Monash Graduate Excellence Scholarship (CK), the Murdoch Children's Research Institute, the Royal Children's Hospital, the Royal Children's Hospital Foundation, the Department of Paediatrics at the University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.